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It's worth noting that while tirzepatide slows gastric emptying, which contributes to its weight loss effects by promoting satiety, there is insufficient evidence to conclude that this directly affects fluid balance or causes thirst through altered fluid absorption patterns
Several studies suggest that similar to lipids, reductions in food intake via intestinal protein in rodents are due to CCK release and subsequent activation of VANs, as (1) intestinal protein infusion increases CCK in rodents and humans 188,189
Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity: the SURMOUNT-4 Randomized Clinical Trial
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