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First characterised by Professor Predrag Sikiric and colleagues at the University of Zagreb in the early 1990s, BPC-157 has since become one of the most widely studied peptides in preclinical research, spanning gastrointestinal biology, musculoskeletal repair, neuroprotection, and cytoprotective signalling

It is extensively studied in preclinical models for its ability to promote dendritic spine formation, enhance synaptic plasticity, and support neuronal regeneration

A second research context involves extracellular matrix components

Xenobiotics can reshape microbial communities, alter spatial organization, and disrupt hostmicrobiota signaling (Sutherland et al., 2020