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Kidney: Use cautiously in patients with kidney disease

It's not always the case but it does come to mind

Dysesthesia (altered skin sensation) as a GLP-1-class effect retatrutide TRIUMPH-1 treatment-emergent rate 5.1 / 12.3 / 12.5% at 4 / 9 / 12 mg vs 0.9% placebo

While efficacy endpoints for weight loss in those trials were modest, the compound exhibited a favorable safety profile, supporting its later GRAS designation for food use

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