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Semaglutide: Targets the GLP-1 pathway only Focuses on appetite regulation and fullness Tirzepatide: Targets both GLP-1 and GIP pathways May create a broader metabolic response Although this difference sounds technical, it can influence how patients respond to treatment
Increased appetite occurs in 6080% of users within the first week, driven by ghrelin receptor agonism in the hypothalamus
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Clinical trials may differ in patient population, baseline weight and BMI, diabetes status, medication dose, treatment duration, nutrition and lifestyle support, dropout rates, side-effect profiles, study design, and whether the data are published, peer-reviewed, or topline results
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