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That is among the highest averages ever reported for a weight-loss medication, which is why retatrutide is considered such a promising step forward
The ESSENCE trial compared Wegovy to placebo rather than other treatments directly
The brief duration of action means that endogenous GLP-1 functions as a meal-related signal rather than providing sustained metabolic control
Therefore, possible mechanisms for the effects of GLP-1RA involve central nervous system effects or peripheral effects on gastric emptying, as alcohol must reach the upper intestine on its path to the brain
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