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GLP-1 receptor agonists, by achieving greater weight loss than obtained with other medications, may represent a therapeutic opportunity for improving obesity in patients with PsO and HS, with resulting decrease in CVR and, in general, improvement in the medium to long term
Following 2 weeks of liraglutide/saline treatment, mice were fasted overnight (12 hours) and given a last dose of liraglutide/saline at 08:00
Blocking SST neurons reduced the second phase of vasodilation (HbT pre/post-CNO: 35.61 7.43/27.81 6.68%, averaged over 2130 s, n = 5 mice, p = 0.0015, paired sample, two-tailed t test), while the initial vasodilation remained mostly intact
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