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For acne scars specifically, we are talking about the flat dark marks (usually brown or red) left after a pimple resolves, not deep pitted scars (which glutathione wouldnt affect since those involve skin texture, not pigment)
This literature is real, but it is smaller than the volume of confident statements about this compound would lead you to expect, and its endpoints are tissue weights, histology and phosphorylation states rather than anything that transfers to another species
10.1161/HYPERTENSIONAHA.110.155663 120 LambertE.StraznickyN.SchlaichM.EslerM.DawoodT.HotchkinE.et al
The evidence supports berberine as a legitimate metabolic support compound producing modest weight loss through multiple mechanisms
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