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The introduction of GLP-1 receptor agonists and subsequent multi-agoniststargeting pathways like GIP, amylin, and glucagonhas revolutionized clinical outcomes
Trials with less than 4000 patient-years of exposure to the drug were excluded according to the updated FDA Guidance for Diabetes Drug Development released in 2020 [8]
The percentages of participants who experienced AE leading to treatment discontinuation as well as of those who experienced gastrointestinal AE with oral semaglutide 50 mg (Tables 2 and 3) were similar to those observed with subcutaneous semaglutide 2.4 mg (in STEP-1 and STEP-2 trials 67% discontinued treatment due to AE, 3444% experienced nausea, 2132% diarrhoea and 2225% vomiting) [11, 29]
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