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Side Effect and Safety Consideration Side Effects of Zepbound Although research on Zepbound is ongoing, the reported side effects are similar to those of other GLP-1 receptor agonists: Nausea Vomiting Diarrhea Constipation Headache Seventy five percent of side effects are considered moderate and the remainder are serious

Fluid retention, dose titration phases, metabolic adaptation, dietary habits, and underlying health conditions can all contribute to unexpected weight changes during treatment

Altered acylcarnitine metabolism is associated with an increased risk of atrial fibrillation