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The initial two stages are devoid of pigmentation but are distinguished by the presence of intraluminal proteinaceous fibrils

Primary bile acids, such as cholic acid and deoxycholic acid, are directly synthesized from cholesterol in the liver, while secondary bile acids, such as lithocholic acid and ursodeoxycholic acid, are formed in the intestine as a result of bacterial metabolism [246, 247]

Assists in supporting skin hydration and texture

Feature selection consistency across folds supported model stability: 5 (of 14) and 15 (of 37) metabolites were repeatedly selected across more than 30 cross-validation folds for urinary and gait models, respectively ( Figure S5B, S5D)