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doi: 10.1038/ejcn.2014.114 31 JothimaniD.VenugopalR.AbedinM
Currently in the UK, injectable GLP-1 receptor agonists such as semaglutide (Ozempic) and dulaglutide (Trulicity) are well-established treatments recommended by NICE (NG28) for specific indications in type 2 diabetes management, with some formulations also approved for weight management
Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis
Maintenance strategies are being studied, including lower maintenance doses after achieving weight loss goals, intermittent dosing schedules, and combination with lifestyle interventions for sustained results
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