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This increase in calcium activates calpain, inducing a conformational change that shifts it into an active state and promotes CDK5 activation through the cleavage of p35 into p25 [46, 47]

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MOTS-c is most effective when combined with structured exercise, adequate protein, and complementary metabolic interventions such as metformin, SGLT2 agents, or GLP-1 therapy under clinical supervision

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These were metabolic and cardiovascular outcomes

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Scientific References Dietary Reference Values for Food Energy and Nutrients for the United Kingdom (Report on Health and Social Subjects No

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