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In Phase 2 clinical trials, participants achieved 24.2% average weight loss at 48 weeks, the highest result ever recorded for an obesity medication in clinical testing

Nevertheless, large database studies continue to show low incidence rates consistent with background population levels

These processes can occur via homosynaptic mechanismssuch as presynaptic dopamine autoreceptors and dopamine transportersas well as heterosynaptic mechanisms, such as retrograde signaling from postsynaptic cholinergic and GABAergic systems, among others

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