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2 Physiology of incretins 2.1 Discoveries of GIP and GLP-1 The first incretin, GIP, was purified from canine intestinal extracts in the late 1960s (8) and initially named gastric inhibitory polypeptide (9) because the peptide inhibited gastrin-stimulated H + secretion (10)

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Biomed Pharmacother 98:118124 Verma R, Tewari V (2016) Some important medicinal plants of cold desert regions of District Kinnaur of Himachal Pradesh state in India: their uses and chemical ingredients