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However, HepG2 cells exposed to a combination of fatty acids exhibited a marked increase in GR gene expression (Longhitano et al

NMDA/Glutamate: There is evidence of interaction with N-methyl-D-aspartate (NMDA) receptors, helping to balance excitatory glutamatergic transmission

Together, they dont just restore damaged tissuethey can often make it stronger and more functional than before the injury

In contrast, NADPH oxidase and p53 (especially acetylation-defective mutant p53) act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively