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Continuous use: ~18% reduction in heart attack, stroke, and death Stop the drug: 6 months +4% risk 1 year +14% 1.5 years benefit erased 2 years +22% risk It takes 3 years to build protection and ~11.5 years to lose it
Starting with lower doses (0.25 mg) and gradually increasing allows assessment of individual tolerance
Duranton, F
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