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USA 122 , e2417626122 (2025)

(OAG) - Oregon, USA Potentially 750,000 records are affected

By identifying the gut microbiome as an active player in the effects mediated by GLP-1 instead of a mere passive factor, this review puts forth a conceptual framework designed to clarify the variability in therapeutic responses and to inform the creation of personalized GLP-1 strategies that take the microbiome into account

Importantly, while menopause is not a disease, it is associated with long-term changes in health and chronic disease risk, including: Increased risk of cardiovascular disease 6 Alterations in glucose and lipid metabolism, leading to increased risk of overweight, obesity, and type 2 diabetes 7 Bone loss and increased risk of osteoporosis 7 Declining muscle mass and strength, and increased risk of sarcopenia 8 Brain changes, cognitive impairment, and increased risk of dementia 7,9 The good news is that there are evidence-based treatment options available that can help