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A therapy that modestly improves mitochondrial reserve or microvascular supply may have little immediate effect on infarct volume but still increase the responsiveness of surviving networks to rehabilitation
The chemical form, copper coordination, concentration and experimental model all materially affect interpretation
The effective range sits between 0.01 and 100 nanomolar, with peak collagen stimulation occurring at just 1 nanomolar
GSH activity is facilitated by activation of the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 that regulates expression of genes controlling antioxidant, inflammatory and immune system responses
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