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Diabetes Prevention Notably, in SURMOUNT-1, tirzepatide reduced the progression from prediabetes to type 2 diabetes by 94% compared to placebo, suggesting strong preventive potential

In cell experiments, GLP-1 was found to have more mechanisms that may inhibit liver fat synthesis, such as FAM3A, NRF2, NaB, SHP1/AMPK, NLRP3, FGF21, IRS2, and other signaling pathways, which also provided direct evidence for the role of GLP-1R in the regulation of lipid metabolism in the liver

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Aging and Increased Oxidation of the Sulfur Pool 18