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GHRP-6: Significant appetite stimulation via ghrelin signaling
For indirect comparison (different trials, populations, and durations), semaglutide showed approximately 50% reduction over 72 weeks, and tirzepatide approximately 47% at 52 weeks
This 47% greater relative weight loss demonstrates the enhanced efficacy of dual GIP and GLP-1 receptor agonism compared to mono GLP-1 receptor agonism ^5
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