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Description

The aim of LT4 treatment, which is the most common and advanced treatment method known for HT, is to normalize thyroid hormone levels by determining the dosage according to patient factors

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SAM also regulates homocysteine hepatic remethylation by inhibiting betaine-homocysteine methyltransferase activity (Fig

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Second-generation inhibitors such as valspodar offered improved potency but interfered with CYP450 enzymes (e.g., CYP3A4), leading to problematic drugdrug interactions

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