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If hiccups persist beyond 48 hours, cause significant sleep or eating disruption, or accompany severe abdominal pain, fever, or signs of pancreatitis or dehydration, seek medical review

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While the Cmax values observed on the first day for all hydrogel-based TZP and Sema formulations might be expected to cause nausea and suppressed food intake in rodents, no changes to animal behavior were observed throughout the study

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