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Reduced TCF7L2 protein levels in T2DM are associated with decreased GIP- and GLP-1 receptor expression and impaired -cell function

The 10 Stages after clinical questions but before legal consents and treatment selection Clinical Safety Screens Performed FDA black-box family history (thyroid cancer + MEN2) Pancreatitis / pancreatic cancer history Gallbladder / gastroparesis history Type 1 diabetes / insulin-dependent check Anorexia / bulimia (in comorbidity list) Sulfonylurea + DPP-4 + insulin drug-interaction list Bariatric / abdominal surgery history with timing granularity Drug/food allergies + dedicated GLP-1 brand-name allergy screen BMI Consent acknowledgment checkbox Side-effect sensitivity question Edens current-medications screen is unusually specific

Plant Physiol 106(3):10071014

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