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There are no strict dietary restrictions with Metformin, but it's best to avoid excessive alcohol due to the risk of lactic acidosis
However, -oxidation yields acetyl-CoA, which enters the TCA cycle by condensation with oxaloacetate for further oxidation
This biomechanical relief can lead to meaningful improvements in osteoarthritis symptoms and physical function over time
As these effects continue, portion control becomes easier and cravings gradually fade
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