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The long-term safety of semaglutide for weight loss is also still under investigation (Davies, et al., 2021)
It also provides cardiovascular benefits, reducing the risk of major adverse cardiovascular events in people with established heart disease
Moreover, GLP-1RA and DPP-4 inhibitors are approved for the treatment of T2DM and exhibit potential pleiotropic effects on the heart and kidneys, which may be independent of or dependent on the hypoglycemic effects
Contrast-induced nephropathy prevention: Multiple RCTs have studied NAC for prevention of contrast-induced kidney injury during coronary angiography
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