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IGF-1 LR3 activates IGF1R with high affinity and can activate hybrid IGF1R/IR receptors to some degree

The FDA prioritises safety and efficacy and has not approved any injectable product for skin whitening

Product quality is a major confounder: research-grade material sold "for research use only" is not manufactured to pharmaceutical standards, and contaminants, incorrect concentrations, or endotoxins can cause harms that have nothing to do with the peptide itself

Ipamorelin, unlike other GHS-R agonists, selectively stimulates only GH release, with no effect on other pituitary hormones such as ACTH or prolactin