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Consistently, AMPK activator AICAR was attenuated, while PARP-1 over-activation aggravated cholesterol-induced toxicity in INS-1 cells, indicating that in islet cells, PARP-1 also regulates cholesterol efflux through AMPK activation and ABCA1 protein, therefore affecting the GLP-1 protection against cholesterol-induced toxicity

There was no significant finding for GSH levels in the medial frontal cortex (g = 0.18 (95% CI, 0.090.44)) (Fig

Clinical patterns: Findings such as early greying may reflect oxidative stress but are considered observational rather than diagnostic

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