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Variants in genes like GIPR determine the baseline sensitivity of your appetite-control pathways, which means some individuals tolerate missed doses better than others while maintaining steady appetite suppression

It activates both glucose-dependent insulinotropic polypeptide (GIP) receptors and glucagon-like peptide-1 (GLP-1) receptors

Statements Author contributions MG and RP have contributed to the conception or design of the work, participated in the drafting of the manuscript and revising it critically for important intellectual content, approved the manuscript for publication and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

More seriously, tirzepatide is not appropriate for people with a personal or family history of medullary thyroid cancer or MEN2 syndrome