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Key Takeaways Starting dose: 2mg once weekly for the first 4 weeks to assess tolerance Titration schedule: Increase every 4 weeks: 2mg 4mg 8mg 12mg (max) Half-life: Approximately 6 days, reaching steady state in 4-5 weeks Injection frequency: Once weekly on the same day each week Microdosing option: Some users split doses for improved tolerability Investigational Drug: Retatrutide is NOT FDA-approved and is currently only available through clinical trials
10.3389/fphar.2019.00411 38 XieZ.EnkhjargalB.WuL.ZhouK.SunC.HuX.et al (2018)
Kidney Int (2014) 85(6):13039
Individuals with a loss-of-function single nucleotide polymorphism (SNP) in the PEMT gene, such as the rs12325817 variant, have a drastically reduced ability to synthesize their own phosphatidylcholine internally
