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There are many unknowns, including dose-response in humans, interactions with other fertility treatments, and differences at various stages of conception including gametogenesis, implantation, and gestation
J Biol Chem 277: 310317 Zapun A, Darby NJ, Tessier DC, Michalak M, Bergeron JJ, Thomas DY (1998) Enhanced catalysis of ribonuclease B folding by the interaction of calnexin or calreticulin with ERp57
Tolerance can reduce during a gap, so restarting at a high dose may cause worse side effects
For lupus patients, protein is especially important because corticosteroids cause muscle wasting, and losing weight without adequate protein intake risks losing muscle mass rather than fat
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