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2018 Sep;38(9):1725-1730

Patients should receive comprehensive counseling about realistic expectations, potential side effects, the importance of continued lifestyle modification, and the need for ongoing nutritional monitoring

Therapeutic resistance represents a major challenge in PC management, particularly as CRPC frequently develops resistance to conventional therapies such as ADT and PARP inhibitors

It also found that there was an overall increase in the risk of breast cancer with menopausal hormone replacement therapy.[ref] HRT in cancer survivors seems to increase the risk of recurrence.[ref] Estrogen Mimics: BPA, Phthalates, and Other Toxicants There are several environmental toxicants that act similarly to estrogen in the body