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Effect of PA on oxidative stress markers The APAP treatment induced a statistically significant increase in MDA level and a decrease in GSH level in mice liver ( p 0.001), while PA produced an improvement in the oxidative stress state by decreasing the MDA level and increasing the GSH level in the APAP + PA group when compared to the APAP group ( p 0.001) (Table 3)
This additional layer of regulation further constrains flavonoid reprogramming under combined stress, highlighting the importance of understanding how regulatory networks coordinate these responses across multiple biological levels
Apart from being unpredictable and long-lasting, these illnesses can affect the overall quality of life
Of these, 2-fold differences in gene expression were identified for 336 gene transcriptsthe most significantly differentially expressed genes are summarised in Supplementary Table 1 (Supplementary Information), and changes in gene expression predicted by BeadChip Array analysis confirmed by qRTPCR analysis for selected up- and downregulated genes (Figure 4)
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