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Type 2 Diabetes and Metabolic Health Glutathione deficiency is commonly observed in type 2 diabetes, driven by hyperglycemia-induced oxidative stress, impaired cysteine availability, and reduced activity of glutathione synthesis enzymes [2][11]
World J Gastroenterol 28:2527
GSH depletion-dependent cell death was prevented by selective ferroptosis inhibitors (8 M Fer-1 and 600 nM Lip-1), iron chelator DFO (80 M), as well as autophagic inhibitors Baf-A1 (75 nM) and 3-MA (10 mM)
Savage JH, Courneya JP, Sterba PM, Macglashan DW, Saini SS, Wood RA
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