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Mild sting or burning: Apply firm pressure for 60 seconds, then leave alone Persistent aching: Cool compress for 10-15 minutes, repeat as needed Itching: Oral antihistamine and/or topical hydrocortisone Small bruise: No treatment needed, resolves in 5-10 days Larger bruise: Cool compress first 24 hours, warm compress after Small lump: Warm compress twice daily, massage gently after 24 hours Lumps or nodules that form at injection sites usually represent localized medication pooling or minor tissue reaction
The STEP 1 trial found that nausea was reported by 44% of participants in the semaglutide group, but the vast majority of nausea episodes were transient and occurred during dose escalation
Nearly all the excitatory mechanisms in the nervous system go into overdrive and, until new adaptations to the drug-free state develop, the brain and peripheral nervous system are in a hyperexcitable state, and extremely vulnerable to stress
While dermatologic reactions are not among the most prominent adverse effects listed in the prescribing information, patients and clinicians have reported various skin-related symptoms during semaglutide therapy
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