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In vivo, it is not actually going to bind to albumin, but [the glycan] has sialic acid moieties, which also reduces the liver metabolism, and thus increases the circulating half-life in the blood, explains Melbourne researcher Chaitra Chandrashekar, who carried out the work

Clinical implication The updated FDA labeling for liraglutide and semaglutide highlights the importance of monitoring depressive symptoms or suicidal thoughts, suggesting treatment discontinuation if such ideations occur [87,88]