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Description

Large cardiovascular outcome trials involving tens of thousands of patientssuch as LEADER (liraglutide), SUSTAIN-6 (semaglutide), and REWIND (dulaglutide)have not demonstrated an increased incidence of medullary thyroid carcinoma or other thyroid malignancies compared to placebo groups

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Subjects on VYVANSE also showed greater improvement on the Clinical Global Impression-Improvement (CGI-I) rating scale compared to subjects on placebo (Study 5 in Table 6)

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Further studies, including final evaluations from regulatory bodies, are warranted to discard a causal link between GLP-1RA and suicidality (shortly before publication of this article, EMA released a news report in line with our findings [39])

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