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What Actuaries Should Watch If nothing else, the rise of GLP1 medications has made one thing clear: These drugs are neither a panacea nor a passing trend

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In the SURMOUNT-1 trial, tirzepatide produced dose-dependent weight reductions, with average losses approaching or exceeding ~20% at higher doses in adults with obesity who did not have diabetes, numbers that markedly exceed historical pharmacotherapy benchmarks

These figures reflect branded medications in controlled clinical settings and should not be interpreted as expected outcomes for compounded versions or any individual patient