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International Journal of Chronic Obstructive Pulmonary Disease, 1 (4), 425-434

FITC-agonist was added for 30 min at 37 C to induce internalization, then removed and washed with cold HBSS to arrest further endocytosis, and cells treated with 500 mM ice-cold sodium 2-sulfanylethanesulfonate (MesNa), a membrane-impermeable reducing agent, in alkaline TNE buffer (100 mM NaCl, 50 mM Tris-HCl, pH 8.6) to cleave BG-SS-biotin specifically from cell surface receptors

Keywords tirzepatide, mounjaro, liver, injury, hepatotoxicity, DILI Introduction Tirzepatide (also known commercially as Mounjaro), a Glucagon-like peptide 1(GLP-1) and glucose-dependent insulinotropic peptide (GIP) receptor agonist, is a drug historically used for management of triple therapy-resistant type two diabetes mellitus

Importantly, tirzepatide can delay gastric emptying, which may reduce the absorption of some oral medications, including oral contraceptives