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FDA reportedly granted GRAS status for one specific oral formulation but not for the injectable peptide
A deficiency of choline can lead to fatty liver and hardening of the arteries
Is the deficiency of vitamin B12 related to oxidative stress and neurotoxicity in Parkinsons patients
Stronger mechanistic clarification would require isoform-specific NOS inhibition, direct measurement of NO metabolites, eNOS phosphorylation analysis, rescue experiments, and comparison across endothelial, epithelial, fibroblast, and neuronal model systems
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