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The process from initial compound discovery to patient availability takes between 10 and 15 years on average
Therefore, GDH activity is differently regulated by stress conditions (Akcay et al
It must be administered directly into the body to be effective
Future investigations should incorporate high-resolution joint-tissue single-cell transcriptomics, long-term OA models, and clinically stratified cohorts to further elucidate the diagnostic utility and mechanistic function of LPCAT3 in OA pathogenesis
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