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There is an increased risk of overdosing or underdosing GLP-1 medications when switching

In the Phase 2 obesity trial, retatrutide 12 mg produced approximately 24.2% mean weight loss at 48 weeks ( Jastreboff et al., NEJM 2023 ), and the Phase 2 type 2 diabetes trial showed strong HbA1c and weight reductions ( Rosenstock et al., Lancet 2023 )

Vascular disease: L-Carnitine has been shown to improve blood flow and reduce inflammation in people with peripheral arterial disease, a condition that can lead to reduced blood flow to the limbs