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Mounjaro works through two incretin hormone pathways, while Ozempic works primarily through GLP-1

But they also directly impact liver health

Factors Influencing Muscle Loss on GLP-1 Drugs Patient-Specific Risk Factors Not everyones body responds the same way to GLP-1 medications

Typical criteria include: Documented diagnosis of type 2 diabetes with inadequate glycemic control on metformin or other first-line agents BMI 27 kg/m with weight-related comorbidity or BMI 30 kg/m (for weight management indications) Trial and failure of alternative therapies Absence of contraindications Coverage for weight management indications under commercial plans has expanded but remains inconsistent, with many employers specifically excluding obesity medications from pharmacy benefits