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Pharmacokinetic predictions for patients with renal impairment: Focus on peptides and protein drugs

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Background There were two GLP-1 products that were initially approved and marketed for treating type-2 diabetes but, because they also had successful weight loss results, the manufacturers each got FDA approval to sell the products under two separate indications, one indicated for type 2 diabetes and one for weight loss, each with its own brand name and National Drug Code (NDC) identification number

4 th experiment: n = 5 mice for each group