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Engineering an improved IgG4 molecule with reduced disulfide bond heterogeneity and increased Fab domain thermal stability
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Mechanistically, research has focused on BPC-157's ability to upregulate VEGF (vascular endothelial growth factor) receptor expression, promote angiogenesis at sites of injury, modulate nitric oxide synthase activity, and support the integrity of the gut lining the tissue environment from which the original protective protein was isolated
doi: 10.1210/jcem.83.2.4551
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