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With the metabolic reprogramming of NADPH, cancer cells increase the demand of NADPH for antioxidative effects and anabolic reactions
The first and rate-limiting step is catalyzed by an enzyme called glutamate-cysteine ligase (GCL), which links glutamate and cysteine together
OGC imports cytosolic GSH into mitochondria in exchange for 2-oxoglutarate (2-OG) and other dicarboxylates
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