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They want to make sure the treatment is safe and effective
In a previous network meta-analysis, a subgroup analysis based on different follow-up durations confirmed that semaglutide had stable effects on reducing HbA1c levels after 3 months
but exogenous estrogen replacement in post-menopausal women was found to have several adverse side effects, therefore this treatment is not recommended (Rajfer et al
However, individual variation exists, and certain populations including older adults, those with baseline sarcopenia, or patients with inadequate protein intake may be at higher risk for clinically significant muscle loss requiring intervention
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