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2 Historical and contemporary perspectives on honey in cancer care The use of honey for medicinal purposes is no less ancient than that of its consuming, it goes back to the times of Egyptian, Greek, Ayurvedic, and Chinese medicine ( 3 Chemical composition and therapeutic attributes of honey Most of the anticancer efficacy of honey is due to the rich profile of polyphenolic and flavonoid constituents, such as gallic acid, caffeic acid phenyl ester, chrysin, and quercetin, which act on oxidative stress, inflammatory pathways, and apoptotic signaling in cancerous cells
This study found that in animals treated with 2-Aminobicyclo [2, 2, 1] heptane-2-carboxylic acid (BCH), a nonmetabolic analogue of leucine, the renal arteriovenous ammonia level change was greater than in the liver, indicating that hyperammonemia in GDH-HI patients is mainly induced due to increased renal ammonia production, instead of abnormalities in urea synthesis in the liver
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