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In September 2025, clinical research was published on weight loss for two oral incretin therapies: an oral version of semaglutide and Orforglipron, also a GLP-1 receptor agonist
Aravindhan, A
The on-demand pathway is designed to reduce the friction of staying on treatment a meaningful problem in the GLP-1 market, where medication discontinuation rates are high and one of the most common reasons patients stop is difficulty getting timely prescription refills
This restrictive surgery reduces stomach capacity, limits food intake, and alters gut hormones that regulate appetite and metabolism
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