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Yabe D, Nakamura J, Kaneto H et al (2020) Safety and efficacy of oral semaglutide versus dulaglutide in Japanese patients with type 2 diabetes (PIONEER 10): an open-label, randomised, active-controlled, phase 3a trial
5-HTP, a precursor to serotonin, supports enteric nervous system function
Safety Considerations at Higher Semaglutide Doses Higher semaglutide doses increase the risk of gastrointestinal side effects, particularly nausea, vomiting, constipation, and diarrhea, though these typically improve with time
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