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4,6,7 Opioid replacement therapy not only mitigates these changes in neurotransmitters but is also associated with apoptosis, white and grey matter injury, altered redox homeostasis, and changes in oligodendroglial maturation and myelination, which may be particularly damaging in the developing brain
I have added a slide from a Novo Nordisk presentation illustrating that participants requiring dose reductions during maintenance tended to enter the study with BMI levels distributed slightly within a lower rangefurther supporting individualized maintenance dosing strategies
Further studies are needed to confirm the results. The researchers also observed there was an increase in the use of second-line noninsulin antidiabetic medications throughout the study period, especially the use of GLP-1 receptor agonists in the U.S., suggesting the number of infants prenatally exposed to these drugs will continue to increase
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